The NFL's injury crisis is hitting harder than ever this season, leaving fans on the edge of their seats as top talents are forced to the sidelines—imagine the heartbreak of watching your favorite quarterback miss game after game! But here's where it gets controversial: are teams playing it too safe with their star players, or is pushing through injuries the real mark of dedication? Stick around as we dive into Week 6's inactives and injury updates, keeping you informed on every twist, from bold calls to surprising comebacks.
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Get the full scoop on the latest injury news and inactive lists for Week 6.
Published on October 12, 2025, at 11:57 am ET • Estimated read time: 3 minutes
Injuries are ramping up across the NFL this year, with some of the league's biggest names sidelined for extended periods. For instance, Baltimore Ravens quarterback Lamar Jackson is out for his second consecutive game due to a hamstring issue, while San Francisco 49ers signal-caller Brock Purdy is also sidelined with a toe injury. These absences highlight how fragile even the elite can be—hamstring pulls often result from explosive movements like sprinting or scrambling, and toe injuries can sideline players for weeks if not managed properly.
Among the notable quarterbacks missing action in Week 6, there's also a high-profile game-time decision. Arizona Cardinals QB Kyler Murray, nursing a foot problem, has been officially ruled inactive for Sunday's matchup against the Colts. This means he won't suit up at all, and Jacoby Brissett will take the helm as the starter—a development that had been building all week based on reports.
While Jackson sits out for the Ravens, wide receiver Zay Flowers (shoulder) was listed as questionable going into the early 1 p.m. games, but he'll be on the field. Similarly, cornerback Christian Gonzalez is active for the Patriots, whereas Anthony Richardson is out as a healthy scratch for the Colts, essentially serving as the backup QB2 despite no injury. And for the Browns, rookie quarterback Shedeur Sanders is active, ready to contribute as the second-string option.
On the Saints' side, running back Alvin Kamara (ankle) was questionable, but he's not on the inactive list and will indeed play. This choice could spark debate—some fans might wonder if pushing an injured star like Kamara is worth the risk, potentially shortening his career, while others see it as a testament to toughness in the NFL.
Shifting to the 4 p.m. games, Bengals wide receiver Ja'Marr Chase is dealing with an illness and is questionable, but he's expected to suit up. Meanwhile, 49ers wide receiver Jauan Jennings has ankle and rib issues, making him questionable as well. These updates remind us how 'questionable' status means a player is doubtful but could still play, often depending on last-minute evaluations.
Stay tuned right here for real-time injury updates on Sunday's contests.
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Anthony Richardson isn't a healthy scratch due to injury; it's an eye issue keeping him out.
Saints' inactives against the Patriots: Alvin Kamara WILL PLAY— a call that might surprise those expecting caution.
Panthers' inactives versus the Cowboys: Rico Dowdle gets the nod to start.
Rams' inactives against the Ravens: Rob Haverstein is missing.
Steelers' inactives versus the Browns: Calvin Austin III is out.
Patriots' inactives against the Saints: Christian Gonzalez is ACTIVE.
Seahawks' inactives versus the Jaguars: Neither Devon Witherspoon nor Riq Woolen are playing.
Ravens' inactives against the Rams: Patrick Ricard, who was questionable, won't play.
Dolphins' inactives versus the Chargers: Nothing unexpected here.
Browns' inactives versus the Steelers: Shedeur Sanders is ACTIVE as QB2.
Chargers' inactives versus the Dolphins: Quinton Johnson is sidelined today.
Cowboys' inactives against the Panthers: Neither CeeDee Lamb nor Tyler Booker are active.
Jaguars' inactives versus the 49ers: No major shocks.
Cardinals' inactives against the Colts: Kyler Murray is out, with Jacoby Brissett starting.
Colts' inactives against the Cardinals: Anthony Richardson is a healthy scratch.
We'll learn soon if Quentin Johnston plays.
Jets' inactives versus the Broncos: Allen Lazard is inactive.
Broncos' inactives versus the Jets: Jonah Elliss is OUT.
And this is the part most people miss: These inactive lists aren't just about injuries—they can reflect strategic decisions, like resting players or making roster calls that change game dynamics. For example, sitting Anthony Richardson as QB2 might be a vote of confidence in the starter, but is it the right move when versatility could be key? Or consider the Saints opting to play Kamara despite his ankle—does this show loyalty to a franchise icon, or is it risking further damage? These choices often divide fans: some praise the grit, others criticize the short-sightedness. What do you think—is prioritizing health over wins becoming too common in the NFL today? Do teams owe it to players to bench them more often? Share your opinions in the comments below—we'd love to hear your takes and debate the pros and cons!
